NHS Digital Data Release Register - reformatted

Institute Of Occupational Medicine (iom)

Project 1 — DARS-NIC-149506-6C4GX

Opt outs honoured: Y

Sensitive: Sensitive

When: 2017/09 — 2017/11.

Repeats: Ongoing

Legal basis: Section 251 approval is in place for the flow of identifiable data

Categories: Identifiable

Datasets:

  • MRIS - Members and Postings Report

Benefits:

At present there is no clear evidence that occupational exposures in the lead manufacturing industry increases workers’ cancer risks. The International Agency for Research on Cancer (IARC) has occupational exposure to inorganic lead as ‘probably carcinogenic to humans’ based on limited evidence of carcinogenicity in humans. Therefore it is a priority to clarify whether exposure increases risk of cancer. This study will identify whether there are any health risks from having worked in the lead manufacturing industry in the UK ( and elsewhere in the pooled information). On completion of this work, there will be a better understanding of whether work in the lead industry poses a cancer risk, and if so what exposures give rise to an increased cancer risk. This analysis is part of the most definitive study of work in this industry ever undertaken and the results will influence and inform international occupational health policy makers, including the Health and Safety Executive. The results will have the potential to directly influence the health and safety policies of the lead industry and the actions they will take will have a direct benefit for workers and reduce the burden on the health system.

Outputs:

Once the processing for this study has been completed, there will exist an international data sets in relation to cancer incidence risks within the lead manufacturing industry. As a consequence of this study the International Agency for Research on Cancer will revisit their classification of work in the lead industry. The institute of Occupational Medicine have strong links with the Health and Safety Executive and will also report their findings directly to the HSE. There will also be a peer-reviewed scientific publication of an analysis of the UK, Finnish and US cancer registration data. This is expected to be published one of the following journals; • Occupational and Environmental Medicine • Journal of Occupational and Environmental Medicine • American Journal of Industrial Medicine It is expected to be submitted for publication mid 2017. Example of a previous publication can be found on BMJ http://oem.bmj.com/content/72/9/625 The relevant Trade Unions will also be informed of the outputs so they can make their members aware.

Processing:

Only substantive employees of Institute of Occupational Medicine (IOM) will have access to the disseminated data and only for the purposes described in this document. Standard Office for National Statistics term s and conditions apply to the mortality data already being held by this study. This cohort is already flagged with NHS Digital. IOM would like to obtain cancer register data linked to the Lead study cohort. Identifiable data is being requested and includes; NHS Number, name, DOB, sex as well as cancer site, type and morphology data and member number. Identifiable data has been requested to ensure the quality of the linkage and the subsequent analysis. The cancer data will be analysed, along with the occupational data (blood lead measurement, factory and process codes) to compare exposures, types and rates and will be compared will national statistics. De-identified data in the format of IARC member number, cancer site, type and morphology linked to occupational data will be supplied to IARC via a secure transfer method. No identifiable data will be shared with IARC, including date of the cancer. IARC do not hold any identifiers for the cohort, so cannot re-identify the cohort on receipt on the data from IOM. IOM are the data controller for the data supplied to IARC. The de-identified data being shared with IARC will be pooled with other international study outputs to increase the statistical information available to inform IARCs classification and occupational policy makers. The Institute of Occupational Medicine are prohibited from providing identifiable data to International Agency for Research on Cancer. The Institute of Occupational Medicine, as Data Controller, are responsible for the disseminated data, including the data shared with the International Agency for Research on Cancer. Therefore, IOM will be considered in breach of this agreement should IARC break any of the conditions of the Data Sharing Agreement agreed between IOM and IARC. If IARC does not respond in a timely manner to a request made for necessary evidence to ensure that the terms of their data sharing agreement with IOM are being abided by, then IOM is responsible for informing NHS Digital of this. IOM are responsible for ensuring that data destruction is completed at IARC when required.

Objectives:

Inorganic lead compounds are classified, by the International Agency for Research on Cancer (IARC) which is an agency of the World Health Organisation, as 'probably carcinogenic to humans'. This is based on ‘sufficient evidence of carcinogenicity in experimental animals’ and 'limited evidence of carcinogenicity in humans’. Much of the epidemiological evidence for carcinogenic effects in humans comes from studies of lead workers. However, previous studies have often involved relatively small numbers of workers and suffered from methodological constraints such as limited information on co-exposures to other risk factors or poorly characterised exposure assessments. Given the length of follow-up, the large size of the cohort and the relatively high exposures that they experienced (as documented by blood lead levels), the proposed study would make a significant contribution to the evidence on the carcinogenicity of lead exposure. This study will fill an important knowledge gap identified as a research priority by IARC.


Project 2 — DARS-NIC-323309-L2G9T

Opt outs honoured: N, Y

Sensitive: Sensitive

When: 2016/04 (or before) — 2017/02.

Repeats: Ongoing

Legal basis: Approved researcher accreditation under section 39(4)(i) and 39(5) of the Statistical Registration Service Act 2007 , Section 251 approval is in place for the flow of identifiable data

Categories: Identifiable

Datasets:

  • MRIS - Cause of Death Report
  • MRIS - Flagging Current Status Report
  • MRIS - Scottish NHS / Registration
  • MRIS - Bespoke

Benefits:

The whole aim of the study is to better understand the burden of disease associated with work in the rubber and cable manufacturing industry and to better understand the nature of exposure-response relationships, for agents known and strongly suspected as causing cancer. This will inform occupational health policy-makers such as the HSE and impact descriptions of optimum working practices in the industry, not just in the UK but throughout Europe and the rest of the world. The outputs from this research will directly benefit those in the industry by identifying risk factors which will inform preventative measures, reducing the risk of disease and the burden on healthcare, It is anticipated that the work will be completed during 2016.

Outputs:

There will be at least three peer-reviewed scientific publications to contain the analyses described above. The names of these publications are: • Extended Follow-up of a cohort of workers in the rubber and cable manufacturing industry. • Dose response relationships in a cohort of workers in the rubber and cable survey. • An international pooled cohort study of workers in the rubber and rubber products manufacturing industry. Results will also be fed back to the Health and Safety Executive and made available to HSCIC and ONS. Outputs will contain no record level data and will be aggregated in line with the requirements of the HES Analysis Guide

Processing:

The Institute of Occupational Medicine (IOM) would receive data from the Health and Safety Executive (HSE) in relation to workers who took part in an original study undertaken by the HSE predecessor in 1967. IOM would then pass NHS number, DOB data and if applicable date of death to the HSCIC to trace the cohort and provide NHS exits, cancer and mortality data to IOM. HSCIC will also trace members of the cohort using the paper records where deaths have occurred before computerisation in 1991. Identifiable mortality data will be received by the IOM part of the research team in order to determine how the mortality and, cancer incidence rates among the cohort, compare to those expected on the basis of the general population for Great Britain. Named IOM researchers will be working with identifiable data to enable the appropriate mortality data to be matched to the correct cohort member.

Objectives:

This research from the Institute of Occupational Medicine (IOM) sets out to determine whether specific chemicals used within the rubber manufacturing process increase the risk of cancer. The aim is to assess whether working in this industry has increased the risk of dying from certain types of cancer, such as lung cancer, bladder cancer, leukaemia and cancers of the larynx, oesophagus, prostate, brain and liver. This will be done by calculating standardized mortality ratios using mortality data for Great Britain. The EXASRUB database, a database of chemical exposures in the European rubber and cable manufacturing industry (see http://exasrub.iras.uu.nl/) will be used to investigate exposure-response relationships to better understand the role of individual chemicals or mixtures of chemicals and any risks that might be identified. The IOM are requesting to track approximately 40,000 workers, who were aged 35 or over in 1967 and worked in the rubber industry, with the HSCIC in order to receive updates in relation to deaths and cancers.


Project 3 — DARS-NIC-335133-K2Y2S

Opt outs honoured: Y

Sensitive: Sensitive, and Non Sensitive

When: 2016/09 — 2017/02.

Repeats: Ongoing

Legal basis: Approved researcher accreditation under section 39(4)(i) and 39(5) of the Statistical Registration Service Act 2007 , Section 251 approval is in place for the flow of identifiable data

Categories: Identifiable

Datasets:

  • MRIS - List Cleaning Report
  • MRIS - Bespoke

Benefits:

At present there is no clear evidence that occupational exposures in the hard-metal manufacturing industry affects the risks of disease, such as lung cancer, or death. The International Agency for Research on Cancer (IARC) has classified this work in the hard metal manufacturing industry as ‘probably carcinogenic to humans’. Therefore it is now a priority to clarify whether exposure increases risk of cancer. This study will identify whether there are any health risks from having worked in the hard-metal manufacturing industry in the UK or elsewhere. On completion of this work, there will be a better understanding of whether work in the hard-metal industry poses a cancer risk, particularly for lung cancer, and if so what agents are implicated. This is the most definitive study of work in this industry ever undertaken and the results will influence and inform occupational health policy makers, including the Health and Safety Executive. The results will directly influence the health and safety policies of the hard metal industry and the actions they will take will have a direct benefit for workers and reduce the burden on the health system.

Outputs:

There will be a peer-reviewed scientific publication of the UK analysis and at least one peer-reviewed publication for the international pooled analysis. These are expected to be published in the following journals; • Occupational and Environmental Medicine • Journal of Occupational and Environmental Medicine • American Journal of Industrial Medicine These are expected to be submitted for publication mid to late 2016. Once the processing for this study has been completed, there will exist national and international data sets in relation to cancer incidence and mortality risks within the industry. It’s possible that the International Agency for Research on Cancer will revisit their classification of work in the hard-metal industry as a consequence of this study.

Processing:

Institute of Occupational Medicine (IOM) aim to carry out an analysis of the mortality experience of workers in the hard-metal manufacturing industry. The mortality data will be linked to occupational histories for individuals within the study cohort in order to determine what role (if any) work in the industry may have had for certain causes of death that are of particular interest on the basis of previous epidemiological studies and toxicological data. IOM will calculate standardised mortality ratios using mortality data for England and Wales and the West Midlands for comparison and also compare mortality rates in those workers with higher exposures to those with lower exposures. HSCIC will supply IOM identifiable mortality, latest demographic data and NHS de-registration data who will perform their analysis against the general population. IOM will supply fully de-identified (as agreed with ONS and specified by CAG) data to the international study coordinators University of Pittsburgh. This will be month and year of birth and death and cause of death data. University of Pittsburgh does not hold any data for these individuals and therefore cannot re-identify this cohort. They will be supplied with a member number in order to check data quality with IOM only. The study ID number will be held electronically at IOM on a separate secure server which is only use for epidemiological studies involving sensitive personal data. A nested case-control study of lung cancer is also planned to take into consideration the influences of lifestyle, such as smoking and employment in other industries. HSCIC will co-ordinate the consenting of this cohort. HSCIC will use the informants details supplied on the death registrations details (as agreed by ONS) to send consent material. IOM will only receive consented participants details. Once an informant of a member of the cohort who died from lung cancer has consented, IOM will conduct a short telephone interview to gather information on lifestyle and employment history of the case. For each of these cases, five controls will be contacted. The controls will be contacted via the HSCIC to either the GP if they are alive to ask for the consent material to be passed on, or via the informant on the death certificate.

Objectives:

At present there is no clear evidence that occupational exposures in the hard-metal manufacturing industry affects the risks of disease, such as lung cancer, or death. This study aims to assess the evidence for or against such associations, by comparing the death rates in those who have worked in the industry with those in the general population. It will also investigate whether death rates differ between those with lower and higher exposures arising from work in the industry.